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1

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

Anderson, N., Borlak, J.

Journal:

Pharmacological Reviews

Year:

2008

Language:

english

File:

PDF, 728 KB

english, 2008

2

Identification and quantification of metabolites of arachidonic acid from cultures of endothelial cells by HPLC-MS 2

Zelinski, V., Borlak, J.

Journal:

Year:

2005

Language:

english

File:

PDF, 248 KB

english, 2005

3

The landscape of hepatobiliary adverse reactions across 53 herbal and dietary supplements reveals immune-mediated injury as a common cause of hepatitis

Zhu, Jieqiang, Chen, Minjun, Borlak, Jürgen, Tong, Weida

Journal:

Archives of Toxicology

Year:

2019

Language:

english

File:

PDF, 3.99 MB

english, 2019

4

Is lipotoxicity an oxymoron?

Friedrich Spener, Rudolf Zechner, Jürgen Borlak

Journal:

European Journal of Lipid Science and Technology

Year:

2006

Language:

english

File:

PDF, 133 KB

english, 2006

5

Phenotyping ofN-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure

Alexander Jetter, Martina Kinzig-Schippers, Michael Illauer, Robert Hermann, Katharina Erb, Jürgen Borlak, Helga Wolf, Gillian Smith, Ingolf Cascorbi, Fritz Sörgel, Uwe Fuhr

Journal:

European Journal of Clinical Pharmacology

Year:

2004

Language:

english

File:

PDF, 342 KB

english, 2004

6

The next innovation cycle in toxicogenomics: Environmental epigenetics

Stella Marie Reamon-Buettner, Vanessa Mutschler, Juergen Borlak

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2008

Language:

english

File:

PDF, 597 KB

english, 2008

7

NKX2–5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD)

Stella Marie Reamon-Buettner, Juergen Borlak

Journal:

Year:

2010

Language:

english

File:

PDF, 415 KB

english, 2010

8

Graft rejection: pharmacogenetic analysis or drug anamnesis?

V. Vi Pham, Dirk O. Stichtenoth, Jürgen Borlak

Journal:

British Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 297 KB

english, 2008

9

Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures

Jürgen Borlak, Thomas Thum

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 645 KB

english, 2001

10

Topoisomerase II inhibition involves characteristic chromosomal expression patterns

Susanne Reymann, Jürgen Borlak

Journal:

Year:

2008

Language:

english

File:

PDF, 299 KB

english, 2008

11

MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure

Thum, T., Galuppo, P., Wolf, C., Fiedler, J., Kneitz, S., van Laake, L. W., Doevendans, P. A., Mummery, C. L., Borlak, J., Haverich, A., Gross, C., Engelhardt, S., Ertl, G., Bauersachs, J.

Journal:

Year:

2007

Language:

english

File:

PDF, 831 KB

english, 2007

12

Lung tumour growth kinetics in SPC-c-Raf-1-BB transgenic mice assessed by longitudinal in-vivo micro-CT quantification

Thomas Rodt, Christian von Falck, Sabine Dettmer, Katja Hueper, Roman Halter, Ludwig Hoy, Matthias Luepke, Juergen Borlak, Frank Wacker

Journal:

Journal of Experimental & Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 397 KB

english, 2012

13

349 Hallmarks of ion channel gene expression in end-stage heart failure

J. Borlak, T. Thum

Journal:

Toxicology Letters

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

14

Recent advances in live cell imaging of hepatoma cells

Sandeep Salipalli,Prafull Kumar Singh,Jürgen Borlak

Journal:

BMC Cell Biology

Year:

2014

Language:

english

File:

PDF, 1.67 MB

english, 2014

15

Primary non-function is frequently associated with fatty liver allografts and high mortality after re-transplantation

Kulik, Ulf, Lehner, Frank, Klempnauer, Jürgen, Borlak, Jürgen

Journal:

Liver International

Year:

2017

Language:

english

File:

PDF, 535 KB

english, 2017

16

Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III

Daniele Passarella, Alessandra Giardini, Bruno Peretto, Gabriele Fontana, Alessandro Sacchetti, Alessandra Silvani, Cristina Ronchi, Graziella Cappelletti, Daniele Cartelli, Jurgen Borlak, Bruno Danie

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.30 MB

english, 2008

17

Verapamil drug metabolism studies by automated in-tube solid phase microextraction

M Walles, W.M Mullett, K Levsen, J Borlak, G Wünsch, J Pawliszyn

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2002

Language:

english

File:

PDF, 331 KB

english, 2002

18

pNAT and CYP2D6 gene polymorphism in epileptic patients

Jürgen T. Borlak, Veronique Harsany, Hansjörg Schneble, Klaus D. Haegele

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 410 KB

english, 1994

19

No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy

Marcin Nowicki, Olga Zabirnyk, Nicole Duerrschmidt, Jürgen Borlak, Katharina Spanel-Borowski

Journal:

European Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 1.57 MB

english, 2007

20

Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels

Zwadlo, C., Borlak, J.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

21

Handbook of Toxicogenomics (Strategies and Applications) || Introduction

Borlak, Jürgen

Year:

2005

Language:

english

File:

PDF, 56 KB

english, 2005

22

ApoE is a major determinant of hepatic bile acid homeostasis in mice

von Hardenberg, Sandra, Gnewuch, Carsten, Schmitz, Gerd, Borlak, Jürgen

Journal:

The Journal of Nutritional Biochemistry

Year:

2017

Language:

english

File:

PDF, 1.02 MB

english, 2017

23

Epidermal growth factor-induced hepatocellular carcinoma: gene expression profiles in precursor lesions, early stage and solitary tumours

Borlak, Jürgen, Meier, Tatiana, Halter, Roman, Spanel, Reinhard, Spanel-Borowski, Katharina

Journal:

Year:

2005

Language:

english

File:

PDF, 270 KB

english, 2005

24

Antibody Conjugated PLGA Nanoparticles for Targeted Delivery of Paclitaxel Palmitate: Efficacy and Biofate in a Lung Cancer Mouse Model

Karra, Nour, Nassar, Taher, Ripin, Alina Nemirovski, Schwob, Ouri, Borlak, Jürgen, Benita, Simon

Journal:

Year:

2013

Language:

english

File:

PDF, 1.80 MB

english, 2013

25

Automated In-Tube Solid-Phase Microextraction Coupled with HPLC for the Determination of N -Nitrosamines in Cell Cultures

Mullett, Wayne M., Levsen, Karsten, Borlak, Jürgen, Wu, Jingcun, Pawliszyn, Janusz

Journal:

Analytical Chemistry

Year:

2002

Language:

english

File:

PDF, 88 KB

english, 2002

26

Toward predictive models for drug-induced liver injury in humans: are we there yet?

Chen, Minjun, Bisgin, Halil, Tong, Lillian, Hong, Huixiao, Fang, Hong, Borlak, Jürgen, Tong, Weida

Journal:

Biomarkers in Medicine

Year:

2014

Language:

english

File:

PDF, 812 KB

english, 2014

27

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

Zhang, Jie, He, Kan, Cai, Lining, Chen, Yu-Chuan, Yang, Yifan, Shi, Qin, Woolf, Thomas F., Ge, Weigong, Guo, Lei, Borlak, Jürgen, Tong, Weida

Journal:

Chemico-Biological Interactions

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

28

Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades

Liu, Zhichao, Wang, Yuping, Borlak, Jürgen, Tong, Weida

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.25 MB

english, 2016

29

Handbook of Toxicogenomics (Strategies and Applications) || The Chemical Effects in Biological Systems (CEBS) Knowledge Base

Borlak, Jürgen

Year:

2005

Language:

english

File:

PDF, 590 KB

english, 2005

30

HNF4alpha and HNF1alpha Dysfunction as a Molecular Rational for Cyclosporine Induced Posttransplantation Diabetes Mellitus

Borlak, Jürgen, Niehof, Monika, Zhang, Baohong

Journal:

Year:

2009

Language:

english

File:

PDF, 301 KB

english, 2009

31

Dissecting Epigenetic Silencing Complexity in the Mouse Lung Cancer Suppressor Gene Cadm1

Reamon-Buettner, Stella Marie, Borlak, Juergen, Castresana, Javier S.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.40 MB

english, 2012

32

Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice

Lee, Eun-Hee, Oh, Jung-Hwa, Selvaraj, Saravanakumar, Park, Se-Myo, Choi, Mi-Sun, Spanel, Reinhard, Yoon, Seokjoo, Borlak, Jürgen

Journal:

Year:

2016

Language:

english

File:

PDF, 3.04 MB

english, 2016

33

Combined Serum and Tissue Proteomic Study Applied to a c-Myc Transgenic Mouse Model of Hepatocellular Carcinoma Identified Novel Disease Regulated Proteins Suitable for Diagnosis and Therapeutic Intervention Strategies

Ritorto, Maria Stella, Borlak, Jürgen

Journal:

Journal of Proteome Research

Year:

2011

Language:

english

File:

PDF, 3.79 MB

english, 2011

34

Dietary Fat and Plasma Lipids

Gurr, M. I., Borlak, Nazeli, Ganatra, Smita

Journal:

Nutrition Research Reviews

Year:

1989

Language:

english

File:

PDF, 1.88 MB

english, 1989

35

WITHDRAWN: Toxicogenomics applied to in vitro toxicology: A cDNA- array based gene expression and protein activity study in human hepatocyte cultures upon treatment with Aroclor 1254

Borlak, Jürgen, Drewes, Jan, Hofmann, Kay, Bosio, Andreas

Journal:

Toxicology in Vitro

Year:

2005

File:

PDF, 12 KB

2005

36

Handbook of Toxicogenomics (Strategies and Applications) || Systems Biology Applied to Toxicogenomics

Borlak, Jürgen

Year:

2005

Language:

english

File:

PDF, 359 KB

english, 2005

37

Handbook of Toxicogenomics (Strategies and Applications) || Investigating the Effective Range of Agents by Using Integrative Modelling

Borlak, Jürgen

Year:

2005

Language:

english

File:

PDF, 405 KB

english, 2005

38

Combined Micro-PET/Micro-CT Imaging of Lung Tumours in SPC-raf and SPC-myc Transgenic Mice

Rodt, Thomas, Luepke, Matthias, Boehm, Claudia, Hueper, Katja, Halter, Roman, Glage, Silke, Hoy, Ludwig, Wacker, Frank, Borlak, Juergen, von Falck, Christian, Muñoz-Barrutia, Arrate

Journal:

Year:

2012

Language:

english

File:

PDF, 333 KB

english, 2012

39

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac

Selvaraj, Saravanakumar, Oh, Jung-Hwa, Borlak, JÃ¼rgen

Journal:

Archives of Toxicology

Year:

2020

File:

PDF, 2.60 MB

2020

40

Synthesis and biological evaluation of novel thiocolchicine–podophyllotoxin conjugates

Daniele Passarella, Bruno Peretto, Raul Blasco y Yepes, Graziella Cappelletti, Daniele Cartelli, Cristina Ronchi, John Snaith, Gabriele Fontana, Bruno Danieli, Jurgen Borlak

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 467 KB

english, 2010

41

A rapid and simple CYP2D6 genotyping assay—case study with the analgetic tramadol

Jürgen Borlak, Robert Hermann, Katharina Erb, Thomas Thum

Journal:

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

42

Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves

Romuald Zabielski, Violetta Leśniewska, Jürgen Borlak, Peter C Gregory, Paweł Kiela, Stefan G Pierzynowski, Wiesław Barej

Journal:

Regulatory Peptides

Year:

1998

Language:

english

File:

PDF, 611 KB

english, 1998

43

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

Kim, Jeong Kyu, Noh, Ji Heon, Jung, Kwang Hwa, Eun, Jung Woo, Bae, Hyun Jin, Kim, Min Gyu, Chang, Young Gyoon, Shen, Qingyu, Park, Won Sang, Lee, Jung Young, Borlak, Jürgen, Nam, Suk Woo

Journal:

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

44

LOX-1 Receptor Blockade Abrogates oxLDL-induced Oxidative DNA Damage and Prevents Activation of the Transcriptional Repressor Oct-1 in Human Coronary Arterial Endothelium

Thum, T., Borlak, J.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 890 KB

english, 2008

45

Genomics of human fatty liver disease reveal mechanistically linked lipid droplet associated gene regulations in blunt steatosis and NASH

Sahini, Nishika, Borlak, Jürgen

Journal:

Translational Research

Year:

2016

Language:

english

File:

PDF, 18.44 MB

english, 2016

46

Gene expression profiling of calcium-channel antagonists in the heart of hypertensive and normotensive rats reveals class specific effects

Zwadlo, Carolin, Borlak, Jürgen

Journal:

Vascular Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.91 MB

english, 2016

47

Handbook of Toxicogenomics (Strategies and Applications) || Databases and Tools for in silico Analysis of Regulation of Gene Expression

Borlak, Jürgen

Year:

2005

Language:

english

File:

PDF, 422 KB

english, 2005

48

Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas

Borlak, Jürgen, Länger, Florian, Chatterji, Bijon

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2018

Language:

english

File:

PDF, 70.38 MB

english, 2018

49

Sensitive method for the determination of KC 12291 in rat plasma and urine by high-performance liquid chromatography

É Tomori, E Tormási, M Varga, J Borlak

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1998

Language:

english

File:

PDF, 93 KB

english, 1998

50

Nifedipine represses ion channels, transporters and Ca2+-binding proteins in hearts of spontaneously hypertensive rats

Carolin Zwadlo, Jürgen Borlak

Journal:

Toxicology and Applied Pharmacology

Year:

2006

Language:

english

File:

PDF, 1.32 MB

english, 2006

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